Isogeometric analysis (IGA) is a newly developed technique that integrates computer-aided design (CAD) with computational methods. The use of non-uniform rational B-splines (NURBS) for the description of geometry and computational domains eliminates discretization errors. Additionally, direct numerical simulation on NURBS entities reduces design-to-analysis time. In the present study, the development of NURBS-based models compatible with the LS-DYNA environment is described, aiming to apply IGA to aero-engine modeling and simulation. Based on this development, a simplified aero-engine model using untrimmed NURBS patches is generated to simulate the dynamics of a rotor accelerating during operation. The simulation of material tests is carried out using IGA, and the results are compared with those obtained by the conventional finite element method (FEM) and experimental data. In addition, the effectiveness of IGA for impact scenarios is investigated through bird strike simulations, and the initial results are compared with FEM and experiments. These results show that IGA can be effectively used to replace traditional methods of modeling and simulation of aero-engines.