In fluid–structure interaction (FSI), a fluid flow and a deforming solid interact along a time-dependent and moving interface, requiring consistent and accurate coupling between the two domains. When large deformations occur, the fluid domain undergoes significant changes. To handle these changes, the Arbitrary Lagrangian-Eulerian (ALE) formulation is commonly used, allowing the reference frame to move arbitrarily and adapt to the deformation. Consequently, the fluid mesh must be continuously updated to maintain accuracy. In this context, we adopt a partitioned FSI framework, which couples the fluid and structure solvers iteratively through a shared interface, allowing each domain to be solved using the best available solvers. Instead of relying on continuous mesh updates, we propose a higher-order, analysis-suitable mesh generation approach, where a new high-quality mesh is generated at every time step without the need for projection between different meshes, taking the deformed FSI interface into account. The generated mesh is then transferred from an Isogeometric Analysis-based structure solver (G+Smo) to the fluid solver through a spline-based coupling method that supports non-conforming FSI simulations. This approach ensures smooth, accurate load transfer while maintaining the continuity of pressure, velocity, and displacement fields, reducing interpolation errors and enhancing the overall stability and efficiency of the partitioned FSI simulation, even in cases of large deformations.